As a member of the fibroblast growth factor family, which interacts with fibroblast growth factors to activate distinct intracellular signaling PI3K/Akt pathways, FGF2 can promote mitosis and vascular activity and is often associated with tumor growth to a certain extent in the field of oncology and has also been regarded as a tumor risk factor [32,33] . This evidence concerns the gene AKT1 and neoplasm.