Interestingly, however, RGS5 increases dramatically in pathological hypoxia (e.g. in tumours or ischaemic stroke), where it is associated with pericyte detachment and migration from the capillaries into the brain parenchyma, resulting in BBB leakage (Hamzah et al., 2008; Ozen et al., 2014, 2018; Roth et al., 2019). The gene discussed is RGS5; the disease is ischemic stroke.