CYP2D6*5 accounted for over 52% of the no‐function haplotypes called from SSA populations, and it occurred most frequently among the participants from Botswana (AF = 13.8%) and South Africa (AF = 14.7%), but it was less frequent among the East and West African population groups, e.g., LWK (AF = 4.7%) and ESN (AF = 3.5%), respectively (Table3). The gene discussed is CYP2D6; the disease is atrial fibrillation.