In further agreement with this finding, we also reported that in ERα‐negative breast cancer cells, mitochondrial stress activates a distinct axis of the UPRmt that is regulated by SIRT3 (Kenny et al., 2017; Kenny, Craig, et al., 2019a; Kenny, Gomez, & Germain, 2019b; Papa & Germain, 2014). Here, SIRT3 is linked to breast cancer.