Finally, NME1 promoted dynamin-mediated endocytosis of the transmembrane metalloproteinase MT1-MMP, known as a key player in tumor invasion, resulting in a strong reduction of surface MT1-MMP levels and a concomitant reduction of extracellular matrix degradation and invasion (Lodillinsky et al., 2021). This evidence concerns the gene NME1 and neoplasm.