Studies using mice deficient in the genes encoding the cluster of differentiation 18 (CD18) and intercellular adhesion molecule 1 (ICAM-1) showed that leukocyte stasis increased within a few days after the onset of diabetes and was associated with increased expression of CD18 and ICAM-1 in the retina (Joussen et al., 2004). Here, ITGB2 is linked to diabetes mellitus.