PIN1 and neurodegenerative disease: For example, Pin1 orthologs from D. rerio (DrPin1), C. elegans (Pinn-1) and D. melanogasta (Dodo) have been linked to neurodegenerative diseases (Del Rosario et al., 2015; Ibarra et al., 2017; Salzberg et al., 2020; Napoletano et al., 2021).