In addition to cancer and neurodegenerative diseases, Pin1 is associated with viral infections and metabolic disease (Lee et al., 2009; Nakatsu et al., 2011; Narita et al., 2013; Nakatsu et al., 2015; Nakatsu et al., 2017; Nishi et al., 2020; Li et al., 2021); however, for brevity, this review will summarily highlight the role of Pin1 in these diseases. This evidence concerns the gene PIN1 and neurodegenerative disease.