Pin1 is involved in many cellular diseases, such as cancer, neurodegenerative disease, viral infections, and metabolic disease, as highlighted in a review by Li et al. (2021) (Lu et al., 1999a; Wulf et al., 2002; Liou et al., 2003; Ryo et al., 2006; Lee et al., 2009; Lim et al., 2011; Nakatsu et al., 2011; Ghosh et al., 2013; Narita et al., 2013; Nakatsu et al., 2015; Nakatsu et al., 2017; Chen et al., 2018; Cheng and Tse, 2018; Nishi et al., 2020; Yu et al., 2020). This evidence concerns the gene PIN1 and neurodegenerative disease.