Significantly, a serine or threonine residue preceding a proline (S/T-P), the specific binding site of Pin1, is the most frequently phosphorylated motif in AD (Lu et al., 2002; Lu et al., 2003; Lu, 2004; Lu and Zhou, 2007; Iqbal et al., 2016; Wang et al., 2020). This evidence concerns the gene PIN1 and Alzheimer disease.