Knockout mice for Tbx1 or double heterozygous knockout mice for Gata4 and Gata6 exhibit fetal nuchal edema with ventricular septal defect (VSD) and persistent truncus arteriosus (PTA) (Vitelli et al., 2002; Xin et al., 2006; Burger et al., 2016). The gene discussed is TBX1; the disease is ventricular septal defect.