LMNA and dilated cardiomyopathy: The most common laminopathy is dilated cardiomyopathy, which is almost exclusively due to heterozygous missense mutations of the LMNA. In the current study, we asked whether the dilated cardiomyopathy-associated p.S143P mutation in LMNA affects turnover and processing of lamins A and C. We found that transcriptional activity and mRNA levels of lamins A and C are increased in patient fibroblasts while their protein levels remain similar to controls.