Furthermore, lamins A and C were increasingly associated with LC3 in patient cells, suggesting that the enhanced rate of autophagy is, at least partially, due to degradation of lamins A and C. In consistent with our results, others have also shown autophagic degradation of lamins A and C. For example, in Hutchinson-Gilford progeria syndrome (HGPS), the E3 ubiquitin ligase SMURF2 was shown to oligo-ubiquitinate lamins A and C and multi-monoubiquitinate progerin for degradation through autophagy (Borroni et al., 2018; Blank, 2020). The gene discussed is SMURF2; the disease is Hutchinson-Gilford progeria syndrome.