ESR1 and breast cancer: In addition, we found in another luminal patient cohort, analyzing both primary tumor and metastasis, that a high AR/ER ratio observed in both samples was associated with a better prognosis, while an AR/PgR ≥1.54 was significantly correlated with worse outcome (HR: 2.27 95%CI: 1.30-3.97; p = 0.004), suggesting its possible role as an additional risk-stratification marker in luminal BC (83).