OGT and obesity due to melanocortin 4 receptor deficiency: Unfortunately, the effect of obesity on O-GlcNAcylation patterns in differentiating adipocytes is not known but the oppositional effects of O-GlcNAcylation on C/EBPβ and PPARɣ in relation to the timing of their adipogenic activities suggests that any shift in the ratio of OGT/OGA activity could delay or inhibit hyperplastic expansion.