At the same time, persistent elevations in adipocyte O-GlcNAc tone as well as macrophage OGT depletion in the face of prolonged overnutrition/obesity are implicated in adipose tissue dysfunctions including a loss of nutrient sensitive lipolysis, increased inflammation, excessive lipid retention, impaired adipocyte differentiation and both local and systemic insulin resistance. This evidence concerns the gene OGT and obesity disorder.