In mouse primary hepatocytes, human hepatoma HepG2 and Huh7 cells, PXR activation inhibits the expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes inhibiting gluconeogenesis (68–70). The gene discussed is NR1I2; the disease is hepatocellular carcinoma.