ACE and chronic kidney disease: After active combined supportive treatment, especially taking ACE inhibitors, the remission rate of proteinuria in diabetic nephropathy was only 26% (13) The 2020 KDIGO guidelines for diabetes management for CKD patients are mainly intended for patients with diabetes and CKD and include recommendations for comprehensive care, lifestyle intervention, blood glucose monitoring, hypoglycemic regimens, and patient management (14, 15).