It has active regulatory effects in a series of diseases, such as acute myocardial infarction, Hashimoto's disease [22–24], and multiple tumors, by targeting the vascular endothelial factor, intercellular adhesion molecule 1, or Ras-association proximate 1/extracellular-signal regulated kinase signaling pathways [25–27]. The gene discussed is ICAM1; the disease is acute myocardial infarction.