ACSL4 and myeloid sarcoma: Previous studies have suggested that microglia contributed to MS in part owing to its sensitivity to iron (Lee et al., 2019; Absinta et al., 2021), and we have previously demonstrated that ferroptosis inhibition or knockdown Acsl4 improved the MS behavioral phenotypes, with reduced neuroinflammation and neuronal death in the EAE mice (Luoqian et al., 2022).