Concerning the serum markers of bone homeostasis, osteocalcin is the bone turnover marker, P1NP is a more sensitive biomarker of bone formation in osteoporosis, and CTX is a specific and sensitive biomarker of bone resorption.(36) Ovariectomy significantly increased the level of these markers, reaching a peak after 14 days. This evidence concerns the gene BGLAP and osteoporosis.