NLRP3 and pulmonary fibrosis: Furthermore, the most recent study showed that NLRP3 inflammasome activation results in ventilator-induced lung fibrosis by promoting pulmonary endothelial cells to undergo EndMT, while NLRP3 deficiency ameliorates EndMT and pulmonary fibrosis in vitro and in vivo [105], suggesting that the suppression of EndMT by NLRP3 inflammasome deactivation may be a feasible strategy against fibrogenesis.