NLRP3 and familial dilated cardiomyopathy: Subsequent studies discovered that rosuvastatin (RSV), a widely used lipid-lowering drug, can improve cardiac function, interstitial fibrosis, and cardiac structural disorders in DCM by inhibiting NLRP3 inflammasome activation, independent of its ability to ameliorate systemic metabolic dysregulation, while these protective effects are attenuated after downregulating NLRP3 [31].