Undeniably, it has been clearly indicated that the dysregulation of the NLRP3 inflammasome plays a key role in the pathogenesis of diabetes, obesity, cardiovascular diseases, cancer, etc. Nevertheless, increasing evidence suggests that its activation could exert a beneficial effect in some forms of cancer, inflammatory diseases, and glucose metabolism and increase plaque stability in atherosclerosis, which reminds us that the beneficial role of the NLRP3 inflammasome should not be ignored [182–186]. The gene discussed is NLRP3; the disease is atherosclerosis.