HMGB1/NF-kB pathway also might be downstream of SIRT1 to inhibit microglia activation and proinflammatory cytokines release in subarachnoid hemorrhage rats and LPS treated BV2 cells (Wang et al., 2019; Zhang et al., 2020a; Li et al., 2020b). This evidence concerns the gene SIRT1 and subarachnoid hemorrhage.