SIRT1 and Parkinson disease: In Parkinson’s disease models, SIRT1 signaling pathway is involved in NLRP3 inflammasome activation in microglia (Zheng et al., 2021), that has been proved again in an subarachnoid hemorrhage mice model in which SIRT1 not only involved in microglia activation, but also M2 microglial polarization (Zhang et al., 2021b).