In a cardiac arrest-related brain injury, researchers used a SIRT1 loss of function approach and found that suppression of SIRT1 compromised the neuroprotection by mild hypothermia treatment both in vivo and in vitro through mediating autophagic flux, they came up with the idea that FOXO1, a transcription factor binds to several consensus sites on the SIRT1 promoter and enables its transcription, might be the upstream of SIRT1 in this model, and further investigation is warranted (Wei et al., 2019). This evidence concerns the gene SIRT1 and cardiac arrest.