However, AK7, the brain-permeable SIRT2 inhibitor, which showed neuroprotective effect in neurodegenerative disease including Parkinson’s disease and Huntington’s disease by protecting dopaminergic neurons against aSyn-induced neurotoxicity in vitro and promotes long-term survival of dopaminergic neurons in vivo, does not show beneficial effects in amyotrophic lateral sclerosis and cerebral ischemia mouse model (Chen et al., 2015b). The gene discussed is SIRT2; the disease is Huntington disease.