Downregulation of SIRT1 is reported to be related with astrocytes activation in PD model, AD model and traumatic brain injury model (Scuderi et al., 2014; Abd El-Fatah et al., 2021; Zhang et al., 2021c; Har-Even et al., 2021; Yang et al., 2022). The gene discussed is SIRT1; the disease is Parkinson disease.