SIRT1 and multiple sclerosis: It was observed that SIRT1 co-localizes with surviving oligodendrocytes in multiple sclerosis plaques, then the research group found a significant reduction in phospho-SIRT1 and SIRT1 expression during oligodendrocytes differentiation, associated with decreased expression of H3K9me3 and increased cyclin D1 (Tatomir et al., 2020).