As astrocyte activation precedes extracellular Aβ deposition, an AD research focused on astrocyte function, and they found that SIRT1 could enhance the ability of astrocytes to clear Aβ, and subsequently essentially delay the formation of amyloid deposits via deacetylating several lysosome-related proteins and upregulate lysosome number (Li et al., 2018). This evidence concerns the gene SIRT1 and Alzheimer disease.