Furthermore, our RNA-seq analysis showed that knockdown of CD36 resulted in downregulation of the expression of genes associated with the “dilated cardiomyopathy”, “hypertrophic cardiomyopathy (HCM)” and “ cardiac muscle contraction” pathways, such as Myh6, Myh7, Tnni3 and Cacng6, in skeletal muscle cells, suggesting that CD36 may have an important regulatory role on skeletal muscle gene expression. Here, TNNI3 is linked to hypertrophic cardiomyopathy.