Signs and symptoms of hypercortisolism and two or more of the following: • P-cortisol >660 nmol/L, and loss of diurnal variation and lack of suppressibility by dexamethasone • S-potassium <3 mmol/L • P-ACTH >22 pmol/L • 22-h urinary free cortisol >400 nmol/day. Here, POMC is linked to adrenal gland hyperfunction.