There are more than 50 DCM-associated genes, but only 12 genes (BAG3, DES, DSP, FLNC, LMNA, MYH7, PLN, RBM20, SCN5A, TNNC1, TNNT2, and TTN) are classified as having a definitive or strong relationship with DCM (4, 5). The gene discussed is PLN; the disease is familial dilated cardiomyopathy.