For future research, the feature optimization method can be used for other polyQ diseases because the relationships between the AAO and genetic modifiers are similar in polyQ diseases, such as SCA1 (Wang et al., 2019), SCA2 (Hayes et al., 2000; Li et al., 2021), and HD (Hmida-Ben Brahim et al., 2014). Here, ATXN2 is linked to Huntington disease.