An evaluation of the correlation between SHMT2 expression and clinical predictors revealed that, with the cumulative amount of SHMT2 in tumour cells, the tumour would further deteriorate in different aspects, including pathological stage (p < 0.001), T stage (p < 0.001), N stage (p < 0.001), and M stage (p < 0.05) (Figures 4B, C). Here, SHMT2 is linked to neoplasm.