In primary hepatic MALT lymphoma, the most frequent translocation is t (14, 18) (q32; q21), which brings the mucosa-associated lymphoid tissue 1 (MALT1) gene to the downstream of the IgG enhancer and makes MALT1 overexpressed, thus resulting in activation of the NF-κB pathway. This evidence concerns the gene MALT1 and MALT lymphoma.