In addition, studies have confirmed that the up-regulation of Notch-1, HES1 and HEY1 genes, overexpression of Snail gene and the aberrant initiation of Wnt/β-catenin signaling pathway are strongly associated with the EMT of CRC cells and resistance to cisplatin drugs (36, 37). This evidence concerns the gene NOTCH1 and colorectal carcinoma.