RETN and carcinoma: The network map of keywords was first built to visualize their clusters, as shown in Figure 8A, we divided the keywords in this filed into 10 clusters, namely “oxaliplatin resistance” (Cluster 0), “multidrug resistance” (Cluster 1), “kinase” (Cluster 2), “colorectal cancer” (Cluster 3), “metastatic colorectal cancer” (Cluster 4), “carcinoma” (Cluster 5), “activation” (Cluster 6), “resistin” (Cluster 7), “kra” (Cluster 8) and “in vivo” (Cluster 9).