The expression of ADH1C, SLC26A2, and NANS was determined in the TCGA-COADREAD dataset (n=689) and four large external cohorts (GSE106582, n=194; GSE31737, n=80; GSE117606, n=208; GSE74602, n=60), and the expression of the three genes were compared between tumor and control tissues. This evidence concerns the gene SLC26A2 and neoplasm.