During cancer progression, several proangiogenic cytokines—such as vascular endothelial growth factor A (VEGFA), fibroblast growth factor (FGF) and hypoxia inducible factor-1 (HIF-1)—which contribute to neovasculature sprouting and formation in the tumor microenvironment (TME), are implicated in immune TME remodeling and direct or indirect immune cell regulation (16–18). This evidence concerns the gene VEGFA and neoplasm.