MPL and anemia: The severe anemia of Mpl–/– Dnm2Plt–/– mice was accompanied by a grossly elevated reticulocyte count of 83.8 ± 23.8%, compared to 7.3 ± 1.4%, 14.6 ± 7.1%, and 13.5 ± 7.0% in Dnm2Plt+/+, Dnm2Plt–/–, and Mpl–/– Dnm2Plt+/+ mice, respectively (P <.001) (Figure 4B).