JAK1 and Autoimmunity: Additionally, targeting JAK3 spares signaling of immunoregulatory cytokines such as IL-10R (TYK2/JAK1), IL-27R (JAK1/JAK2), and IL-35R (JAK1/JAK2) (98), whose activity may contribute to the prevention of autoimmunity to the hair follicle, potentially making a selective JAK3 inhibitor a more potent strategy than pan-JAK inhibition.