CCL2 is considered to be an essential mediator of the inflammatory response in the arterial vascular system.The CCL2/CCR2 axis has been shown to play a critical role in vascular inflammation, vascular remodeling, and vascular hypertrophy via monocyte infiltration and macrophage recruitment in a mouse model of hypertension (10, 28). The gene discussed is CCL2; the disease is Hypertension.