SLC5A2 and hypertensive disorder: The high prevalence of these histologic alterations may have considerable implications for the renal adaptive mechanisms involved in glomerular hemodynamics, since arterioles with hyalinosis may have hampered mechanisms of vasoconstriction and vasodilation through which they exert their role in intraglomerular HTN, which could affect current nephroprotective treatments in T2DM such as renin-angiotensin-aldosterone system (RAAS) blockers and sodium/glucose cotransporter 2 inhibitors (SGLT2i) [17, 18].