In recent years, it has been gradually found that BGN is closely related to the occurrence and development of various malignant tumors, such as endometrial cancer [14], ovary cancer [15], pancreatic adenocarcinoma [16], esophageal squamous cell carcinoma [17], colorectal cancer [18], and prostate cancer [21]. The gene discussed is BGN; the disease is esophageal squamous cell carcinoma.