Interestingly, the high level of miR-31 reduced the levels of APP and BACE1 mRNAs in the hippocampus of 17-months-old AD triple-transgenic (3xTg-AD) female mice, and improved memory deficits and cognitive inflexibility (Barros-Viegas et al., 2020[14]). Here, BACE1 is linked to Alzheimer disease.