Researchers also observed NOR1-positive signals in neurons and Schwann cells in the spinal cord of patients suffering from Lewy body disease but not tauopathies, Tar DNA binding protein 43 kDa (TDP-43) proteinopathies, and polyglutamine disorders, suggesting that pathologically elevated NOR1 in α-synucleinopathy may be involved in the pathogenesis of neurodegenerative diseases (Kon et al., 2015). This evidence concerns the gene NR4A3 and neurodegenerative disease.