Another study by Bonta et al. showed that NOR1 mRNA can be checked in macrophages with atherosclerotic lesions and that overexpression of NOR1 reduces the expression and production of IL-1β, IL-6, IL-8, macrophage inflammatory protein-1, and monocyte chemoattractant protein-1 (MCP-1) in cultured THP-1 cells, whereas silencing of the NOR1 gene has an opposite effect (Bonta et al., 2006). Here, NR4A3 is linked to Atherosclerotic lesion.