NR4A3 and leukemia: This hypothesis may be supported by recently published studies: 1) Z-ligustilide (Z-LIG), a major component of Ligusticum wallichii, was found to suppress the proliferation of human AML cells by promoting the recruitment of Ace-H3 (lys9/14) to the NOR1 promoter, thereby up-regulating NOR1 expression (Table 1) (Wang J. et al., 2021); and 2) SNDX-275, a histone deacetylase inhibitor, was found to promote pro-apoptotic signaling in leukemia cells in part by inducing NOR1 expression (Table 1) (Zhou et al., 2013).