Similar to AML and DLBCL, where NOR1 gene abrogation contributes to the rapid postnatal development of AML in mice, it was also found that reduction of NOR1 expression was sufficient to induce mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) in mice (Ramirez-Herrick et al., 2011). This evidence concerns the gene NR4A3 and myeloproliferative neoplasm.