At the pathological level, the increase in NOR1 expression in the liver should also be reinforced, because researchers also observed a significant increase in NOR1 mRNA expression in the liver in db/db mice and in a mouse model of type II diabetes induced by streptozotocin treatment, and partial inhibition of NOR1 activity by Nur77-M1 (an activation domain mutant of Nur77) in db/db mice can cause a significant decrease in both fasting and random-fed blood glucose levels (Pei et al., 2006). This evidence concerns the gene NR4A1 and type 2 diabetes mellitus.