NR4A3 and triple-A syndrome: For example, studies by Qing et al. (2017) showed that although NOR1 deficiency in hematopoietic stem cells can block the LPS-induced pro-inflammatory response in macrophages, this alteration had no effect on the development of AAA formation in bone marrow-derived stem cell transplanted mice with low-density lipoprotein receptor deficiency, suggesting that macrophage-derived inflammation does not contribute to the development of AAA.