ICI-related myocarditis is characterized by elevated levels of serum cardiac biomarkers (troponin T/I), brain natriuretic peptide (BNP), or NT-proBNP (N-terminal pro-BNP), new LV impairment, and the presence of active myocardial inflammation as revealed by cardiac MRI or endomyocardial biopsy (Chen et al., 2020). This evidence concerns the gene NPPB and myocarditis.