Further research found that both endogenous and exogenous miR-139-5p may limit the proliferation of F. nucleatum-related CRC by provoking tumor-specific proteins, such as c-Myc and cyclin D1 (Zhao et al., 2020), demonstrating the potential therapeutic value of endogenous or exogenous miRNA in CRC. This evidence concerns the gene CCND1 and neoplasm.