A total of 133 KEGG pathways has been found to be associated with the hub genes, among 133 pathways EGFR tyrosine kinase inhibitor resistance, Proteoglycans in cancer, Pathways in cancer, Prostate cancer, Endocrine resistance, and PI3K-Akt signaling pathway were the most significantly enriched pathways. The gene discussed is EGFR; the disease is cancer.