The uninhibited but enhanced expression of ICAM-1 in pathological state can improve the specific distribution of ICAM-1-targeting delivery systems in the lesion site (especially in the lung) and reduce the systemic side effects, which has great potential applications and important significance in the diagnosis and drug delivery of cancer, cardiovascular, lung, genetic, and other diseases, especially in the diagnosis and treatment of inflammation (Hsu et al., 2012). This evidence concerns the gene ICAM1 and cancer.