We investigated the effect of cotreatment of TP and TNF-α in vivo; however, the distribution of TNF-α in the tissue is so quick that there is no difference in the level of TNF-α in the serum and tumor tissue groups after iv injection of TNF-α (10 μg/kg) into the tail vein, although there might be some differences in the levels of miR-204-5p and H19 between the TP/TNF-α and TNF-α-treatment groups. Here, H19 is linked to neoplasm.