In addition, researchers proved that TNF-α delivery can enhance the antitumor activity of antibody-dependent cell–mediated cytotoxicity of an anti-Melanoma Immunoglobulin, peptide anticancer vaccine, and cancer cell membrane targeting therapy (Probst et al., 2019b; Murer et al., 2019; Zhuang et al., 2020b). Here, TNF is linked to melanoma.