INS and Disorder of lipid metabolism: Disorders in lipid metabolism will affect the function of pancreatic beta cells, and then cause or aggravate IR, while a deficiency in IR and insulin secretion will further aggravate lipid metabolism disorders, forming a vicious cycle, leading to the gradual aggravation of IR and insulin secretion disorders as well as lipid metabolism disorders (Engelgau et al., 2000; Wakabayashi and Daimon, 2013).