The endogenous differential metabolite lysophosphatidylcholine (LPC) generates phosphatidylcholine (PC) under the action of phosphatidylcholine acyltransferase 1 (Lpcat1), PC loses the fatty acid at sn-2 position under the action of phospholipase A2 (PLA2), and generates LPC, which is converted into lysophosphatidic acid (LPA) under the catalysis of hemolytic phospholipase D. When liver cancer occurs in the body, lecithin cholesterol acyltransferase (LCAT) synthesis decreases and the level of Lyso PC in blood lowers significantly (Guri et al., 2017). This evidence concerns the gene LPCAT1 and liver cancer.