The insomnia-related targets related to insomnia were screened based on data obtained from the Genecards (https://www.genecards.org/) and OMIM (https://omim.org/) databases, and a total of 2,934 targets including synuclein alpha, interleukin 6, delayed sleep phase syndrome, proline dehydrogenase 1, and restless legs syndrome were collected (Supplementary Table S2). Here, PRODH is linked to insomnia.