Other groups are exploring the association between variants in PNPLA3-TM6SF2-GCKR-MBOAT7 in order to design polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into the causal relationship between NAFLD and hepatocellular carcinoma (HCC) and to stratify risk of HCC. The gene discussed is GCKR; the disease is hepatocellular carcinoma.