The G variant in PNPLA3 was recorded in 53% of cases, thus demonstrating that PNPLA3 I148M accounts for more than half of the interethnic variability in predisposition to liver disease, especially steatosis, steatohepatitis, and fibrosis of varying origin (viral, alcohol, or metabolic) (Karlsen, 2009). The gene discussed is PNPLA3; the disease is steatosis.