In APA-negative and APA-positive groups, the past medical history of coronary artery disease was 29.4% and 18.2% (p = 0.668), atrial fibrillation was 29.4% and 18.2% (p = 0.668), stroke was 17.6% and 45.4% (p = 0.120), peripheral artery disease was 23.5% and 27.3% (p = 1.000) and cancer was 23.5% and 18.2% (p = 1.000), respectively. A statistically significant association between smoking history and APA positivity status was noted in our study. Here, ENPEP is linked to stroke disorder.