In Table 4, we also performed the multivariate regression analysis to determine independent predictors for CHD and diabetes in smokers taking the ACE level as the dependent variable showed that triacylglycerol (TAG) (p=0.014), HDL (p=0.013), LDL (p<0.001), MDA (p<0.0001), ox-LDL (p<0.001), total antioxidant capacity (p=0.002), hs-CRP (p=0.001), MMP-9 (p=0.001), smoking intensity (p=0.002) and smoking burden (p=0.003) were significantly associated with higher ACE level. This evidence concerns the gene MMP9 and diabetes mellitus.