In Table 3 the multivariate regression analysis was performed to determine independent predictors for CHD in smokers taking the ACE level as the dependent variable showed that HDL (p=0.044), LDL (p=0.008), MDA (p=0.013), OX-LDL (p=0.001), total antioxidant capacity (p=0.016), hs-CRP (p=0.011), MMP-9 (p=0.015), smoking intensity (p=0.020) and smoking burden (p=0.003) were significantly associated with higher ACE level. The gene discussed is MMP9; the disease is coronary artery disorder.