Sleep disturbances can cause increased sympathetic excitability, increase resting heart rate, increase myocardial oxygen consumption; Constriction of peripheral blood vessels, and increased peripheral blood pressure, causing essential hypertension; Sympathetic activity is one of the main factors of ventricular remodeling, α adrenaline receptors, β adrenaline receptors and norepinephrine are closely related to the occurrence and development of myocardial hypertrophy and fibrosis, which indicates that sleep disorders are associated with the development of hypertension (22). Here, PPIB is linked to essential hypertension.