PPIB and sleep disorder: Sleep disturbances can cause increased sympathetic excitability, increase resting heart rate, increase myocardial oxygen consumption; Constriction of peripheral blood vessels, and increased peripheral blood pressure, causing essential hypertension; Sympathetic activity is one of the main factors of ventricular remodeling, α adrenaline receptors, β adrenaline receptors and norepinephrine are closely related to the occurrence and development of myocardial hypertrophy and fibrosis, which indicates that sleep disorders are associated with the development of hypertension (22).