CNR2 and Alzheimer disease: Overall, our results indicate that 1 weekafter a specific lesionof BFCN, which damages the same cholinergic pathways that are degeneratedin the early stages of AD, the neuroinflammatory process is characterizedby increased microglia and decreased astrocyte immunoreactivities.In cortical BFCN projection areas, CB1 receptor couplingto Gi/0-proteins is upregulated, while at the lesion site,the area showing the highest increase of microglia, slight CB2 coupling to Gi/0-proteins was detected.