CNR1 and Alzheimer disease: The regulationof neurotransmission under neurodegenerative conditionsmodulates eCB signaling, but the contribution of the two main cannabinoidreceptors, CB1 and CB2, remains to be elucidated.There is evidence about the involvement of CB1 cannabinoidreceptor in both patients and animal models of AD,19,20 but the role of the other main cannabinoid receptor, CB2, is not yet well understood.