The lncRNA Hox Antisense Intergenic RNA (HOTAIR) represents one of the most studied and characterized lncRNAs; it is encoded within the Homeobox C (HOXC) locus and is found upregulated in several cancers [1, 2], in CCl4-induced mouse liver fibrosis models, human fibrotic livers and hepatic stellate cells (HSCs) activated upon TGF-β1 stimulation [3]. This evidence concerns the gene HOTAIR and Hepatic fibrosis.