Xu et al. (2019) revealed a combined chemotherapy and photodynamic therapy by transporting the MMP2-triggered nanodrugs into the tumor sites. Lee et al. (2015) used MMP2 and constructed a double-chambered protein nanocage loaded with γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP) for sepsis treatment. In the present study, we found that the expression of MMP2 was upregulated in sepsis in vivo and in vitro. The gene discussed is MMP2; the disease is Sepsis.