EVs from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF-1α-mediated promotion of angiogenesis in a rat model of stabilized fracture (Zhang et al., 2019), EVs from bone marrow mesenchymal stem cell promote repair of damaged endometrium (Yao et al., 2019), promote metastasis of lung cancer cells (Zhang et al., 2019). The gene discussed is HIF1A; the disease is lung carcinoma.